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11th International Symposium of Tohoku University Global COE Programme Global Nano-Biomedical Engineering Education and Research Network Centre
-Nano-Biomedical Engineering in the East Asian-Pacific Rim Region-


■Lecture 1

"Nouvel Coupling of Boundary Integral and Finite Element Methods for the Fluid Structure Interactions of a Microcapsule in Flow"

Anne-Virginie Salsac
(Researcher, Université de Technologie de Compiègne, Bioengineering Department, Laboratory Biomechanics and Bioengineering (UMR CNRS 6600), France)

We introduce a novel method to study the fluid-structure interaction between a microcapsule and an external flow. An explicit finite element method is used to model the large deformation of the capsule wall, which is treated as a bidimensional hyperelastic membrane. It is coupled with a boundary integral method to solve for the internal and external Stokes flows. The new method is validated by comparison of the results with previous studies in a classical test case: a capsule in a simple shear flow. The method is found to be numerically stable, efficient and in very good agreement with previous studies.

■Lecture 2

"Molecular Understanding of Mammalian Auditory System"

Hiroshi Wada
(Professor, Department of Bioengineering and Robotics, Graduate School of Engineering, Tohoku University)

High sensitivity of mammalian hearing is realized by the motility of outer hair cells in the inner ear. The origin of such motility is considered to be the molecular motor, prestin, which is expressed in the plasma membrane of the outer hair cells. However, the structure of prestin has been unclear. In the present study, we proposed a novel technique for the molecular imaging, immune atomic force microscopy. By such technique, an attempt was made to clarify the structure of prestin.


■Lecture 3

"Electrochemistry-Based Advanced Biodevices"


Matsuhiko Nishizawa
(Professor, Department of Bioengineering and Robotics, Graduate School of Engineering, Tohoku University)

The interfacing between the biomolecules and device materials is one of the most important subjects for both in-vitro and in-vivo biodevices. For example, the biological fuel cell is an electrochemical bionic device that uses enzymes as electrode catalysts for electricity generation from common solutions containing glucose like a fresh juice and our body fluids. The key to obtain higher power is the suitable interfacing between the enzyme reactions and the electric circuit. In addition to the fuel cell research, I will introduce our recent progress in developments of protein and cellular chips integrated in the microfluidic channel systems.

■Lecture 4

"Recent Micro-Nano Robotics and Biomedical Applications"

Fumihito Arai
(Professor, Department of Bioengineering and Robotics, Graduate School of Engineering, Tohoku University)

Micro-nano robotics plays an important role to supply advanced devices and equipments in Bio-medical engineering and science. There is an increasing interest in miniaturization and integration of medical devices by MEMS/NEMS technologies. Recent progress enables us to build manipulators and mobile robots for minimally invasive surgery. Another interest is in manipulation technology for works from millimeter to nanometer scale. These works contribute to elucidate the mechanism of the cell system, realize gene expression control, and regenerate tissue by function control with mechanical stimuli. This talk will provide recent research works on Micro-nano robotics and biomedical applications.



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