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Seminar - Newest Information(Detail)
[Cancelled]
Co-hosted with Program for Exploring Advanced Interdisciplinary Frontiers (S. Deguchi, Dept. Biomedical Engineering)
Endothelial Cell Mechanosensitivity - from Large Arteries to the Microcirculation
We regret to announce that this seminar has been cancelled due to Tohoku earthquake.
| Date | Wednesday 16 March 2011 10:30-12:00 |
|---|---|
| Place | Lecture Hall, Graduate School of Biomedical Engineering Nano-Biomedical Engineering Research Building (Aobayama Campus) |
| Outline |
(Ph.D., Assistant Professor, Department of Biomedical Engineering, Texas A&M University) Endothelial Cell Mechanosensitivity - from Large Arteries to the Microcirculation Endothelial cells lining blood vessels are exceptionally sensitive to the mechanical forces generated by blood flow and pressure. In most regions of the large arteries, fluid shear stress and cyclic stretching of the vessel wall induce axial alignment of the endothelial cells. The unique mechanical environment at arterial branches and curvatures inhibit endothelial alignment and promote a dysfunctional endothelial phenotype conducive to the development of atherosclerotic plaques. Integrated experimental and theoretical modeling studies will be discussed that have revealed a dynamic relationship between the temporal patterns of matrix deformation, actin cytoskeletal reorganization and signal transduction. In particular, these studies indicate non-muscle myosin II plays a pivotal role in allowing endothelial cells to adapt to their mechanical environment to maintain tensional and functional homeostasis. Angiogenesis occurring in the microvasculature is also regulated by the local mechanical environment. It has long been recognized that fluid forces can stimulate microvascular growth, but little attention has been directed toward understanding the underlying mechanisms. To initiate angiogenesis, endothelial cells must be first induced to invade into the underlying extracellular matrix. Results from recent experiments exploring the molecular pathways regulating flow-induced endothelial cell invasion into extracellular matrices will be discussed. |
| Contact | GCOE secretariat Tel: 022-795-7005 |
