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54th NanoBME Series Seminar
Hemodynamic Stresses and Intracranial Aneurysm
| Date | Tuesday 14 December 2010 15:00-16:30 |
|---|---|
| Place | Lecture Hall, Graduate School of Biomedical Engineering Nano-Biomedical Engineering Research Building (Aobayama Campus) |
| Outline |
(Professor of Mechanical, Aerospace and Biomedical Engineering and Neurosurgery, University at Buffalo, The State University of New York, Buffalo, New York Visiting Professor, Institute of Fluid Science, Tohoku University, Sendai, Japan) Hemodynamic Stresses and Intracranial Aneurysm Aneurysm is a cerebrovascular pathology that remains poorly understood and difficult to manage. However, increasing evidence shows that hemodynamics play critical roles in the initiation, growth and rupture of aneurysms. Since hemodynamic stresses at the aneurismal lesion or susceptible arterial locations can be readily obtained noninvasively through imaging and computational fluid dynamics, hemodynamics potentially offers a new and effective way for understanding, diagnosing, risk stratification and treatment planning for patient-specific aneurysms. To this end, understanding the mechanistic links between hemodynamics and aneurysm is very important. In this talk, I will introduce a series of studies at our lab that employs combinations of engineering, biological and medical tools to probe into the role of hemodynamics in cerebral aneurysm pathophysiology. Studies in two in vivo models, complimented by in vitro experiments, demonstrate that abnormal hemodynamic stresses on the endothelium of arterial bifurcations in the flow acceleration zone could trigger pathological remodeling of the arterial wall, leading to aneurysm initiation. Furthermore, analysis of 114 human intracranial bifurcations, distributed amongst major bifurcation sites within and around the Circle of Willis, shows a qualitative correlation between the hemodynamic stresses in the flow acceleration zone at each location and the known susceptibility of aneurysm formation in humans at that location. Therefore, abnormal hemodynamic stresses in the flow acceleration zone, above certain thresholds, are critical in aneurysm pathogenesis. I will also briefly discuss the role of hemodynamics in aneurysm growth and rupture, specifically focusing on results from a recent study of 119 aneurysm cases including both uruptured and unruptured ones. |
| Contact | GCOE secretariat Tel: 022-795-7005 |
