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51st NanoBME Series Seminar
Pulmonary Cell Mechanics
| Date | Thursday 19 August 2010 15:00-16:30 |
|---|---|
| Place | Lecture Hall, Graduate School of Biomedical Engineering Nano-Biomedical Engineering Research Building (Aobayama Campus) |
| Outline |
(Cell and Respiratory Biomechanics laboratory, Mondor Institute of Biomedical Research(UMR955), Inserm and University of Paris East, France) Pulmonary Cell Mechanics Cell mechanics provides an integrated view of many biological phenomena which are intimately related to cell structure and function. Because breathing constitutes a sustained motion synonymous with life, pulmonary cells are normally designed to support permanent cyclic stretch without breaking, while receiving mechanical cues from their environment. The mechanical response of pulmonary cells, mainly alveolar epithelial cells, macrophages, and pulmonary microvascular endothelial cells is studied, in relation to actin structure, through well-controlled mechanical stress using a cytoskeleton-specific micromanipulation technique called magnetic bead twisting cytometry, potentially applicable in vivo. We discuss the pertinence of various microrheological models used to extract cell mechanical properties in relation with cell stress/strain hardening properties, structural models1 and consider more specifically the contribution of adhesion to cell mechanical properties and cell sensitivity to substrate stiffness2. Overall, pulmonary cells provide pertinent cellular models to study normal and pathological biological processes governing cellular response to controlled stress or strain as well as to extracellular environments of various mechanical properties. 1. Féréol et al., Cell Mechanics of alveolar epithelial Cells (AECs) and Macrophages (AMs), Respiratory Physiology.& Neurobiology., 163: 3-16, 2008 2. Féréol et al., Prestress and Adhesion site dynamics control cell sensitivity to substrate stiffness, Biophysical Journal, 96: 2009-2022, 2009 |
| Contact | GCOE secretariat Tel: 022-795-7005 |
