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9th NanoBME Series Seminar
Cellular Force Transmission and Mechanotransduction
| Date | Thursday 13 March 2008 15:00-16:30 |
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| Place | 21COE/REDEEM Lecture Hall, Biomedical Engineering 21COE/REDEEM Building (Aobayama Campus) |
| Outline |
(The Germeshausen Professor of Mechanical and Biological Engineering at MIT) 「Cellular Force Transmission and Mechanotransduction」 Cells are exquisitely sensitive to mechanical force, and respond in a variety of ways, both beneficial and pathological. While biologists have contributed enormously to our understanding of the biochemical signaling pathways that transmit these responses, limited progress has been made in identifying force transmission through the cell or the event in which a mechanical force is first transduced into a biochemical signal. Several mechanisms have been proposed, and some have been characterized, but there is still much to learn. In the process of studying the interactions between force and biology, a new field, “mechanobiology,” has emerged at their interface, and a new term has been coined, “mechanomics,” to encompass the state of stress and its biological consequences. This talk will address some of the theories of mechanical force transmission and transduction, the role of mechanics at multiple length-scales, and some computational models that can help aid in our understanding of these essential phenomena. |
| Contact | COE secretariat Tel: 022-795-7005 E-mail: secretary@nanoBME.org |
