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5th NanoBME Series Seminar
| Date | Thursday 6 December 2007 15:00-16:30 |
|---|---|
| Place | Biomedical Engineering 21COE/REDEEM Building, 21COE/REDEEM Building Hall in System of Mt. Aoba-yama Campus Engineering Research Course |
| Outline |
（Associate Professor and Director, MechanoBiology Laboratory Departments of Orthopaedic Surgery, Bioengineering, Mechanical Engineering and Materials Science, and Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, PA, USA） 「Mechanical Forces, Cells, and Cell Mechanobiology」 Mechanical forces such as gravity, tension, compression, shear, and hydrostatic pressure constantly act on the human body and play an important role in physiology and patho- physiology. Moreover, mechanical forces exert profound effects on cell biology. In this presentation, I will first discuss how externally applied forces induce cell reorientation response and actin cytoskeletal remodeling, followed by a description of our work on biological responses of tendon fibroblasts to mechanical loading. Next, I will present our newly developed technologies, including cell traction force microscopy (CTFM), for measuring traction forces of both single cells and populations of cells. Finally, I will discuss various bio-applications of CTFM, including determination of the relationship between α-SMA expression and cell traction force and analysis of mechanical stress-regulation of cell proliferation and differentiation pattern formation. |
| Contact | COE secretariat Tel：022-795-7005 |
